For a few days now I’ve been using Gmail as my primary email, rather than my Dreamhost IMAP mailbox. I have email addresses for each of my domains, plus individual throw-away addresses for shopping at different sites. Until now they were all forwarded to my Dreamhost mailbox, but I changed them to forward to Gmail instead.
The main reason was that it was too much of a pain to sync my email between Leopard and my default OS and between my MacBook Pro and my iMac with Mail.app, but I find that I’m starting to prefer Gmail’s web interface. I use Google Notifier and keep gmail open at all times, so it’s just as quick & convenient as Mail.app. I can now access my email from my Macs or Linux without syncing.